I had three aurae the last seven days. There has been no real change in my medications. I'm still taking brand Topamax, I got a refill of Teva's lamotrigine a couple weeks ago, and the most recent refill of protriptyline was from the preferred Roxanne instead of Barr. I've been taking Watson's lame-ass 5mg methylphenidate for the last two months.
The first thing I did is stop the methylphenidate. That didn't do it. So I stopped drinking caffeine and doing crossword puzzles. That worked for a couple of days, allowing me to get the grocery shopping down. Then on Friday I have another one, and I can't figure out why. The only thing that was different was the addition of extra nutmeg in my breakfast.
I'm eating cream of buckwheat with bananas. With my sense of smell diminishing I'm having to overspice everything. Nutmeg as a seizure trigger? I know that people get high off of nutmeg, so it's possible. After I wake up from my lorazepam-induced nap I ask the Google about it. All I can find in the literature about nutmeg and seizures or epilepsy is an article on using nutmeg oil as an anticonvulsant for toxin-induced seizures in critters. I was able to find plenty of posts on various epilepsy support sites where people have reported nutmeg as a seizure trigger. So no more nutmeg for me. Blander gluten-free banana bread and I may as well forget about gluten-free gingerbread men. The list of items for the permanent Lent gets bigger all the time.
Maybe if I can find out why nutmeg gets people high I could determine if it's a trigger. What do I find?
Towards a better understanding of the psychopharmacology of nutmeg: Activities in the mouse tetrad assay Sure. Seeing how something affects mice is legit. Even better they compared nutmeg with marijuana, amphetamines and morphine.
How did they compare the effects of those four substances? By measuring the ass temperatures of the mice. Seriously guys? How the fuck do people get grant money that results in something like this:
While oral administration of all the nutmeg extracts at 500 mg/kg caused a significant increase in locomotor activity, the i.p. administration of DE showed significant reduction in rectal temperature along with a significant increase in tail flick latency at 300 mg/kg
They note various physical reactions, but the study was designed around rectal thermometers. I wonder if focusing on inserting things into rectums had something to do with how they got their degrees as well as the grant money.
Some of the recently suggested studies from the latest incarnation Crazy Meds forum that no one is likely to do:
The chain of drug-supplement interactions between retinol, chloramphenicol acetyltransferase (CAT), UGTs and Lamictal.
SSRI's disturb the normal dream generation by the 'primitive' part of the brain which is more emotional and relaxing and instead trigger frontal lobe dream generation which is focused on the rational and on problem-solving. This would also be the reason why many people have nightmares on SSRI's. (A few studies have been done on SSRIs affecting dreams, but not like this.)
I had so many more on previous incarnations of the forum.
I think I went a little overboard by doing the Sunday crossword puzzle. I should have done yesterday's. I was feeling off prior to this post, it hasn't been getting any better. Make that four aurae in eight days.
So I'm stuck, for now, staying stupid, staying tired and mildly depressed, and now with even less flavor.